type ix collagen การใช้

• Hetch et al . also discovered type IX collagen accumulated within the Pseudoachondroplasia chondrocytes.
• This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage.
• Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen.
• Studies conducted by Hetch et al . suggest that type IX collagen, a collagen active specifically in the construction of cartilage, plays a key role in pseudoachondroplasia.
• This discovery indicated the pathogenesis of Pseudoachondroplasia results from the interactions of the products of the mutant COMP allele with certain  cartilage components,  particularly with type IX collagen ( Hetch et al . 1995 ).
• This discovery suggests that the pathogenesis of pseudoachondroplasia involves the interactions of the mutant COMP gene products with specific cartilage components, such as type IX collagen, and that it is not solely the result of the effects of mutant molecules on the production and secretion of COMP ( OMIM 2008 ).